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Image Search Results
Journal: Frontiers in Immunology
Article Title: RORα-activated mitophagy attenuating hypoxic-ischemic encephalopathy via suppression of microglial cGAS-STING axis
doi: 10.3389/fimmu.2025.1592737
Figure Lengend Snippet: Effects of RORα overexpression and mitophagy inhibition on cognitive function, motor ability, ROS levels, and mitochondrial function in an HIE rat model. (A) Illustration of a Morris Water Maze Test. (B) Morris water maze test assessing cognitive function in HIE and treatment groups, measured by the average time to find the platform; (C) Tail suspension test evaluating motor ability in HIE and treatment groups, indicated by the total active time; (D) DHE staining assessing ROS levels in brain tissue from the HIE group and various treatment groups; (E) TEM imaging showing mitochondrial structural changes in brain tissue of HIE and treatment groups; (F) RT-qPCR analysis of free mtDNA release in brain tissue of HIE and treatment groups. Data are presented as mean ± SEM, with N=5 per group. Statistical analysis was performed using ANOVA followed by Tukey’s post hoc test, where * p < 0.05, ** p < 0.01, and *** p < 0.001.
Article Snippet: Briefly, frozen brain tissue sections were incubated with 16 μM
Techniques: Over Expression, Inhibition, Suspension, Staining, Imaging, Quantitative RT-PCR